High sugar diet increased uric acid ncbi

By | August 2, 2020

high sugar diet increased uric acid ncbi

The primary sources of fructose are sugar sucrose and high fructose corn syrup. First, fructose intake correlates closely with the rate of diabetes worldwide. Second, unlike other sugars, the ingestion of excessive fructose induces features of metabolic syndrome in both laboratory animals and humans. Third, fructose appears to mediate the metabolic syndrome in part by raising uric acid, and there are now extensive experimental and clinical data supporting uric acid in the pathogenesis of metabolic syndrome. Fourth, environmental and genetic considerations provide a potential explanation of why certain groups might be more susceptible to developing diabetes. Finally, we discuss the counterarguments associated with the hypothesis and a potential explanation for these findings. If diabetes might result from excessive intake of fructose, then simple public health measures could have a major impact on improving the overall health of our populace. A lthough diabetes was described by Aretaeus, Galen, and Paracelsus, by the mid to late s William Prout 1 and others recognized that diabetes could have two presentations: one manifesting as a rapidly progressive and wasting condition in a thin and feeble individual likely type 1 diabetes, and a slower and more progressive disease in an overweight or obese subject likely type 2 diabetes 1, 2. Similarly, a dramatic increase in diabetes was observed in a number of tropical countries 5.

Furthermore, increased rates of diabetes have been observed in Japanese and Filipinos after immigration to the United States and Canada , In vitro study found that isolated pancreatic islets under high uric acid condition decreased basal and glucose-induced insulin secretion [ 32, 33 ]. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Fiorentino T. Moreover, vitamin C and caffeine both trended towards an inverse association SUA base without passing correction for multiple testing and no difference by race. Finally, it is likely that insulin resistance will continue to manifest once an animal develops extensive fat stores via classical mechanisms 10, so that continued insulin resistance might be expected even if fructose intake was reduced. Ibrahim JG, Molenberghs G. Niskanen L. Hughes V.

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Sugar increased high uric ncbi diet acid

Effects of high-fructose corn syrup lowering uric acid with benzbromarone of fructose and acute metabolic and hemodynamic responses in healthy. One small study showed that with congestive heart failure Broughton. The increased expression of KHK. Choi HK, Curhan G.

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